However, things begin going awry after Homelander arranges for the creation of the Supe Terrorists to create enemies only Vought had the means to combat, which results in Compound V being exposed to military personnel and the higher-ups during raids on terrorist compounds, resulting in major scrutiny towards Vought and Compound V being evaluated by the FDA. Due to her good work, it was Edgar's wish that Stillwell replace him as CEO of Vought. Vought's goal was to get the Seven into the military and perhaps a number of other supes. Vought's goal has always been to capitalize on supes, cutting deals with independent cities and states for protection Madelyn Stillwell tried to offer Baltimore's Nubian Prince at the price of $300 million a year, however the deal was tanked by Homelander. Hughie Campbell was able to stop the Compound V shipments by threatening to release damaging information to the public about Samaritan's leader, Ezekiel. Instead, Compound V was shipped across the US to hospitals by Samaritan's Embrace under the guise of medical supplies. Compound V is shrouded from the public, who are led to believe that supes are chosen by God.

At some point after Vought died, Stan Edgar would take over as CEO and (perhaps like his predecessor) would cover up any casualties caused by the supes. This prompted President Franklin Roosevelt to pardon him in 1944 and allow him to continue his research on Compound V and create more supes (most notably Soldier Boy) and gave him his own corporation to further the development of the supes as an advanced race of living weapons. When Vought realized that the Nazi Party's defeat was certain, he defected from Nazi Germany and the Allied forces smuggled him to the US and allowed him to give his newly developed Compound V to military soldiers to increase their odds against the Nazis. Vought eventually created the first dose of Compound V and had his first successful superhero, his own wife, Klara Risinger. Vought was founded by Frederick Vought, a Nazi scientist whom Adolf Hitler himself appointed as the chief physician at the Dachau concentration camp in 1939 where Vought would perform unethical experimentation on human test subjects in order to develop Compound V to enhance human beings into what are now known as ' Supes'.

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